Noxious input to the spinal cord is known to produce central sensitization, which consists of allodynia , exaggeration of pain, and punctuate hyperalgesia , extreme sensitivity to pain. Two types of mechanical hyperalgesia can occur: 1) touch that is normally painless in the uninjured surroundings of a cut or tear can trigger painful sensations (touch-evoked hyperalgesia), and 2) a slightly painful pin prick stimulation is perceived as more painful around a focused area of inflammation (punctuate hyperalgesia). Touch-evoked hyperalgesia requires continuous firing of primary afferent nociceptors, and punctuate hyperalgesia does not require continuous firing which means it can persist for hours after a trauma and can be stronger than normally experienced. In addition, it was found that patients with neuropathic pain, histamine ionophoresis resulted in a sensation of burning pain rather than itch, which would be induced in normal healthy patients. This shows that there is spinal hypersensitivity to C-fiber input in chronic pain. 
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Dogfighting is an insidious underground organized crime and all dog fighters, regardless of their level, embrace many peripheral crimes and gang activities including drug dealing and consumption, gambling, theft, and violence against humans. [ 44 ] Dogfighting is an incredible source of income for gangs and drug traffickers. In fact, the average dog fight could easily net more money than an armed robbery, or a series of isolated drug transactions. Organized dog fights are staged by leaders of the drug trade as forums to distribute narcotics. Many recent dog fighting raids, include those in Flint, MI (2003), Buffalo, NY (2004), Port St. Lucie, FL (2004), Jones County, GA (2004), and Oklahoma City, OK (2004), have resulted in the infiltration of major drug distribution networks, and the arrest of the drug kingpins who regularly organized and attended the dog fights. [ 45 ]